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Additional information Supervising Editor: Eric J Lavonas, MD, MS Publishers Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

However, in patients with severe renal impairment, a 22% higher mean exposure was observed compared to patients with normal renal function

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Glutamate released from neurons is taken up by glial cells and converted to glutamine before being returned to neurons as the raw material for further neurotransmitter synthesis (257)